FEATURES

FAMILY

zinc-containing alcohol dehydrogenase family

DESCRIPTION

Also known as QOR_HUMAN, CRYZ. Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1, 2-naphthoquinone or 9, 10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CRYZ

Quinone oxidoreductase

CRYZ

Molecular Synopsis