FEATURES

FAMILY

DESCRIPTION

Also known as M3K12_HUMAN, MAP3K12, ZPK. Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. Homodimer (By similarity). Interacts with MBIP (PubMed:10801814).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MAP3K12

Mitogen-activated protein kinase kinase kinase 12

MAP3K12

Molecular Synopsis