FEATURES

FAMILY

DESCRIPTION

Also known as PRDX4_HUMAN, PRDX4. Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. Homodimer; disulfide-linked, upon oxidation (PubMed:9388242). 5 homodimers assemble to form a ring-like decamer (PubMed:21994946). Can form heterodimers with PRDX1 (PubMed:9388242).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PRDX4

Peroxiredoxin-4

PRDX4

Molecular Synopsis