FEATURES

FAMILY

DESCRIPTION

Also known as PD2R_HUMAN, PTGDR. Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1, 4, 5-trisphosphate (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PTGDR

Prostaglandin D2 receptor

PTGDR

Molecular Synopsis