FEATURES

FAMILY

short-chain dehydrogenases/reductases (SDR) family

DESCRIPTION

Also known as DHRS2_HUMAN, DHRS2, SDR25C1. Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3, 4-Hexanedione, 2, 3-Heptanedione and 1-Phenyl-1, 2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21. Directly interacts with MDM2; this interaction occurs in the nucleus and does not target DHRS2 to degradation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DHRS2

Dehydrogenase/reductase SDR family member 2, mitochondrial

DHRS2

Molecular Synopsis