FEATURES

FAMILY

DESCRIPTION

Also known as PPIL2_HUMAN, PPIL2. Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). Interacts with isoform 2 of BSG (PubMed:15946952). Interacts (via the PPIase cyclophilin-type domain) with CRNKL1; they may form a trimeric complex with HSP90.

EXTERNAL LINKS

PPIL2

RING-type E3 ubiquitin-protein ligase PPIL2

PPIL2

Molecular Synopsis