FEATURES

FAMILY

DESCRIPTION

Also known as TNK1_HUMAN, TNK1. Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. Interacts with the SH3 domain of PLCG1 via its Pro-rich domain.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TNK1

Non-receptor tyrosine-protein kinase TNK1

TNK1

Molecular Synopsis