FEATURES

FAMILY

DESCRIPTION

Also known as ERG1_HUMAN, SQLE, ERG1. Catalyzes the stereospecific oxidation of squalene to (S)-2, 3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. Interacts (via N-terminal domain) with MARCHF6. Interacts with SMIM22; this interaction modulates lipid droplet formation (PubMed:29765154).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SQLE

Squalene monooxygenase

SQLE

Molecular Synopsis