FEATURES

FAMILY

DESCRIPTION

Also known as NR1I3_HUMAN, NR1I3, CAR. Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. Interacts with ECT2 (By similarity). Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity). Interacts with CRY1 (By similarity). Interacts with CRY2 in a ligand-dependent manner (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NR1I3

Nuclear receptor subfamily 1 group I member 3

NR1I3

Molecular Synopsis