FEATURES

FAMILY

DESCRIPTION

Also known as ACOX1_HUMAN, ACOX1, ACOX. Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. First enzyme of the fatty acid beta-oxidation pathway., Shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length., Is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1, 16-hexadecanodioyl-CoA. Homodimer (PubMed:32169171). Interacts with LONP2 (PubMed:18281296).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ACOX1

Peroxisomal acyl-coenzyme A oxidase 1

ACOX1

Molecular Synopsis