FEATURES

FAMILY

FAD-binding oxidoreductase/transferase type 4 family

DESCRIPTION

Also known as DHC24_HUMAN, DHCR24, KIAA0018. Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis (PubMed:11519011, PubMed:21671375, PubMed:25637936, PubMed:22178193). In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress (PubMed:11007892, PubMed:22010141). Also protects against amyloid-beta peptide-induced apoptosis (PubMed:11007892). Interacts with DHCR7; this interaction regulates DHCR7 activity.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DHCR24

Delta(24)-sterol reductase

DHCR24

Molecular Synopsis