FEATURES

FAMILY

bacterial solute-binding protein 5 family

DESCRIPTION

Also known as CNTA_STAA8, cntA, opp-1A, opp1A. Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP). Involved in the import of divalent metals ions such as nickel, cobalt and zinc. Binds the metal via the metallophore StP, and transfers the StP-metal complex to the membrane-bound permease (PubMed:23279021, PubMed:29581261). Binds one molecule of StP/metal. Binds StP/Co(2+) and StP/Ni(2+) tighter than StP/Zn(2+) (PubMed:29581261). Plays a major role in nickel/cobalt import in zinc-depleted conditions. Contributes to virulence. Required for full urease activity in vitro (PubMed:23279021). The complex is composed of two ATP-binding proteins (CntD and CntF), two transmembrane proteins (CntB and CntC) and a solute-binding protein (CntA).

EXTERNAL LINKS

cntA

Metal-staphylopine-binding protein CntA

cntA

Molecular Synopsis