FEATURES

FAMILY

DESCRIPTION

Also known as MOGT2_HUMAN, MOGAT2, DC5, DGAT2L5. Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MOGAT2

2-acylglycerol O-acyltransferase 2

MOGAT2

Molecular Synopsis