FEATURES

FAMILY

DESCRIPTION

Also known as CBPC2_HUMAN, AGBL2, CCP2. Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. Interacts with RARRES1, KIF11 AND MAPRE1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

AGBL2

Cytosolic carboxypeptidase 2

AGBL2

Molecular Synopsis