FEATURES

FAMILY

DESCRIPTION

Also known as ZDH20_HUMAN, ZDHHC20. Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:27153536, PubMed:29326245, PubMed:33219126). Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation (PubMed:27153536). Has a preference for acyl-CoA with C16 fatty acid chains (PubMed:29326245). Can also utilize acyl-CoA with C14 and C18 fatty acid chains (PubMed:29326245).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ZDHHC20

Palmitoyltransferase ZDHHC20

ZDHHC20

Molecular Synopsis