FEATURES

FAMILY

DESCRIPTION

Also known as ERAP2_HUMAN, ERAP2, LRAP. Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys. Heterodimer with ERAP1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ERAP2

Endoplasmic reticulum aminopeptidase 2

ERAP2

Molecular Synopsis