FEATURES

FAMILY

class-I pyridine nucleotide-disulfide oxidoreductase family

DESCRIPTION

Also known as TRXR3_HUMAN, TXNRD3, TGR, TRXR3. Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity). Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TXNRD3

Thioredoxin reductase 3

TXNRD3

Molecular Synopsis