FEATURES

DESCRIPTION

Also known as MIB1_HUMAN, MIB1, DIP1, KIAA1323, ZZANK2. E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. Interacts with CEP131 and PCM1.

Also known as MIB1_HUMAN, MIB1, DIP1, KIAA1323, ZZANK2. E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates t ...

EXTERNAL LINKS

MIB1

E3 ubiquitin-protein ligase MIB1

MIB1

Molecular Synopsis