FEATURES

FAMILY

DESCRIPTION

Also known as GLT15_HUMAN, GALNT15, GALNTL2. Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GALNT15

Polypeptide N-acetylgalactosaminyltransferase 15

GALNT15

Molecular Synopsis