FEATURES

FAMILY

zinc-containing alcohol dehydrogenase family

DESCRIPTION

Also known as PTGR3_HUMAN, ZADH2, PTGR3. Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ZADH2

Prostaglandin reductase 3

ZADH2

Molecular Synopsis