FEATURES

FAMILY

DESCRIPTION

Also known as DTX2_MOUSE, Dtx2. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1.

EXTERNAL LINKS

Dtx2

Mutations

Mutation(s) distribution

Mutations table