FEATURES

FAMILY

Organic cation transporter (TC 2.A.1.19) family

DESCRIPTION

Also known as S22AH_HUMAN, SLC22A17, BOCT, BOIT. Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SLC22A17

Solute carrier family 22 member 17

SLC22A17

Molecular Synopsis