FEATURES

FAMILY

DESCRIPTION

Also known as TRI41_HUMAN, TRIM41, RINCK. E3 ligase that plays essential roles in innate antiviral response (PubMed:29899090, PubMed:31979016). Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquitination and proteasomal degradation, thereby limiting viral infections (PubMed:29899090, PubMed:31979016). Participates in innate antiviral response also by mediating 'Lys-63'-linked polyubiquitylation of BCL10 which in turn hubs NEMO for activation of NF-kappa-B and IRF3 pathways (By similarity). Catalyzes the ubiquitin-mediated degradation of other substrates including protein kinase C, ZSCAN21 or TOP3B suggesting additional roles besides its function in immune response (PubMed:17893151, PubMed:33378676). Interacts with PRKCA (PubMed:17893151). Interacts with NOD2 (PubMed:27812135). Interacts with TRIM17; this interaction prevents TRIM41 activity on ZSCAN2 (By similarity).

EXTERNAL LINKS

TRIM41

E3 ubiquitin-protein ligase TRIM41

TRIM41

Molecular Synopsis