FEATURES

FAMILY

DESCRIPTION

Also known as MT21A_HUMAN, METTL21A, FAM119A, HCA557B. Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8. Interacts with heat shock protein 70 family members; at least some of these proteins are methylation substrates (PubMed:23349634 and PubMed:23921388).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

METTL21A

Protein N-lysine methyltransferase METTL21A

METTL21A

Molecular Synopsis