FEATURES

FAMILY

DESCRIPTION

Also known as ATRIP_HUMAN, ATRIP, AGS1. Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. Interacts with ATR (By similarity). Heterodimer with ATR. The heterodimer binds the RPA complex and is then recruited to single-stranded DNA. Interacts with CEP164 (via N-terminus). Interacts with CINP.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ATRIP

ATR-interacting protein

ATRIP

Molecular Synopsis