FEATURES

FAMILY

DESCRIPTION

Also known as VCO3_NAJKA, VCO3. Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity. Heterotrimer of alpha, beta and gamma chains; disulfide-linked. Is active with factor B in the presence of factor D.

EXTERNAL LINKS

VCO3

Cobra venom factor

VCO3

Molecular Synopsis