FEATURES

FAMILY

DESCRIPTION

Also known as ASM3B_HUMAN, SMPDL3B, ASML3B, ASMLPD. Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity). Interacts with TLR4, TLR7, TLR8 and TLR9.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SMPDL3B

Acid sphingomyelinase-like phosphodiesterase 3b

SMPDL3B

Molecular Synopsis