FEATURES

FAMILY

DESCRIPTION

Also known as PCSK5_HUMAN, PCSK5, PC5, PC6. Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PCSK5

Proprotein convertase subtilisin/kexin type 5

PCSK5

Molecular Synopsis