FEATURES

FAMILY

DESCRIPTION

Also known as XPF_HUMAN, ERCC4, ERCC11, XPF. Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link. Heterodimer composed of ERCC1 and ERCC4/XPF. Interacts with SLX4/BTBD12; this interaction is direct and links the ERCC1-ERCC4/XPF complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ERCC4

DNA repair endonuclease XPF

ERCC4

Molecular Synopsis