FEATURES

DESCRIPTION

Also known as TNR25_HUMAN, TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1. Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4.

Also known as TNR25_HUMAN, TNFRSF25, APO3, DDR3, DR3, TNFRSF12, WSL, WSL1. Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and ind ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TNFRSF25

Tumor necrosis factor receptor superfamily member 25

TNFRSF25

Molecular Synopsis