FEATURES

FAMILY

cation transport ATPase (P-type) (TC 3.A.3) family

DESCRIPTION

Also known as AT2A3_HUMAN, ATP2A3. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. Interacts with sarcolipin (SLN) (By similarity). Interacts with phospholamban (PLN) (By similarity). Interacts with myoregulin (MRLN). Interacts with DWORF (By similarity). Interacts VMP1 (PubMed:28890335).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ATP2A3

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

ATP2A3

Molecular Synopsis