FEATURES

FAMILY

DESCRIPTION

Also known as OTUD5_HUMAN, OTUD5. Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Interacts with TRAF3.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

OTUD5

OTU domain-containing protein 5

OTUD5

Molecular Synopsis