FEATURES

FAMILY

DESCRIPTION

Also known as ERO1A_HUMAN, ERO1A, ERO1L. Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1, 4, 5-trisphosphate receptor IP3R1. Predominantly monomer. May function both as a monomer and a homodimer. Interacts with PDILT.

EXTERNAL LINKS

ERO1A

ERO1-like protein alpha

ERO1A

Molecular Synopsis