FEATURES

FAMILY

DESCRIPTION

Also known as NSUN5_HUMAN, NSUN5, NSUN5A, WBSCR20, WBSCR20A. S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA (PubMed:23913415, PubMed:31428936, PubMed:31722427). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (PubMed:31428936, PubMed:31722427). Required for corpus callosum and cerebral cortex development (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NSUN5

28S rRNA (cytosine-C(5))-methyltransferase

NSUN5

Molecular Synopsis