FEATURES

DESCRIPTION

Also known as TRPM7_HUMAN, TRPM7, CHAK1, LTRPC7. Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF-induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). Homodimer. Interacts with PLCB1 (By similarity). Forms heterodimers with TRPM6.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TRPM7

Transient receptor potential cation channel subfamily M member 7

TRPM7

Molecular Synopsis