FEATURES

FAMILY

SLC26A/SulP transporter (TC 2.A.53) family

DESCRIPTION

Also known as S26A8_HUMAN, SLC26A8, TAT1. Acts as a DIDS-sensitive anion exchanger mediating chloride, sulfate and oxalate transport. May fulfill critical anion exchange functions in male germ line during meiosis and hence may play a role in spermatogenesis. May be involved in a new regulatory pathway linking sulfate transport to RhoGTPase signaling in male germ cells. A critical component of the sperm annulus that is essential for correct sperm tail differentiation and motility and hence male fertility. May form a molecular complex involved in the regulation of chloride and bicarbonate ions fluxes during sperm capacitation. Interacts with RACGAP1. Interacts with CFTR.

EXTERNAL LINKS

SLC26A8

Testis anion transporter 1

SLC26A8

Molecular Synopsis