FEATURES

FAMILY

DESCRIPTION

Also known as CSF3R_HUMAN, CSF3R, GCSFR. Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. Homodimer. The dimeric receptor binds two CSF3 molecules. Interacts with CEACAM1; down-regulates the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CSF3R

Granulocyte colony-stimulating factor receptor

CSF3R

Molecular Synopsis