FEATURES

FAMILY

DESCRIPTION

Also known as SOST_HUMAN, SOST. Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SOST

Sclerostin

SOST

Molecular Synopsis