FEATURES

FAMILY

short-chain dehydrogenases/reductases (SDR) family

DESCRIPTION

Also known as DHRS4_HUMAN, DHRS4, SDR25C2. Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DHRS4

Dehydrogenase/reductase SDR family member 4

DHRS4

Molecular Synopsis