FEATURES

FAMILY

short-chain dehydrogenases/reductases (SDR) family

DESCRIPTION

Also known as BDH2_HUMAN, BDH2, DHRS6, SDR15C1. Dehydrogenase that mediates the formation of 2, 5-dihydroxybenzoic acid (2, 5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria (By similarity). Also acts as a 3-hydroxybutyrate dehydrogenase (PubMed:16380372). Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

BDH2

3-hydroxybutyrate dehydrogenase type 2

BDH2

Molecular Synopsis