FEATURES

FAMILY

DESCRIPTION

Also known as EIF2A_HUMAN, EIF2A. Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

EIF2A

Eukaryotic translation initiation factor 2A

EIF2A

Molecular Synopsis