FEATURES

FAMILY

DESCRIPTION

Also known as GPR61_HUMAN, GPR61, BALGR, GPCR3. Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). May be involved in the regulation of food intake and body weight (By similarity). Forms heterodimer with MTNR1B (PubMed:28827538). Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR61 in the endosomal compartment (PubMed:28827538).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GPR61

G-protein coupled receptor 61

GPR61

Molecular Synopsis