FEATURES

FAMILY

DESCRIPTION

Also known as PA2GF_HUMAN, PLA2G2F. Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids (phospholipase A2 activity), the catalytic efficiency decreasing in the following order: phosphatidylglycerols > phosphatidylethanolamines > phosphatidylcholines > phosphatidylserines (PubMed:11112443). May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PLA2G2F

Group IIF secretory phospholipase A2

PLA2G2F

Molecular Synopsis