FEATURES

FAMILY

DESCRIPTION

Also known as SIK2_HUMAN, SIK2, KIAA0781, QIK, SNF1LK2. Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Interacts with and phosphorylates TORC2/CRTC2.

Also known as SIK2_HUMAN, SIK2, KIAA0781, QIK, SNF1LK2. Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. In ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SIK2

Serine/threonine-protein kinase SIK2

SIK2

Molecular Synopsis