FEATURES

FAMILY

DESCRIPTION

Also known as TAOK3_HUMAN, TAOK3, DPK, JIK, KDS, MAP3K18. Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF). Self-associates. Interacts with ERN1 and TRAF2. Interaction with TRAF2 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation.

Also known as TAOK3_HUMAN, TAOK3, DPK, JIK, KDS, MAP3K18. Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Ac ...

EXTERNAL LINKS

TAOK3

Serine/threonine-protein kinase TAO3

TAOK3

Molecular Synopsis