FEATURES

FAMILY

DESCRIPTION

Also known as S12A5_HUMAN, SLC12A5, KCC2, KIAA1176. Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (PubMed:24668262). Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SLC12A5

Solute carrier family 12 member 5

SLC12A5

Molecular Synopsis