FEATURES

FAMILY

DESCRIPTION

Also known as TASP1_HUMAN, TASP1, C20orf13. Protease responsible for KMT2A/MLL1 processing and activation (PubMed:14636557). It also activates KMT2D/MLL2 (By similarity). Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A (By similarity) (PubMed:14636557). Intramolecular proteolysis generates 2 subunits, alpha and beta, which reassemble through a non-covalent association to form the fully active enzyme.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TASP1

Threonine aspartase 1

TASP1

Molecular Synopsis