FEATURES

DESCRIPTION

Also known as DCTP1_HUMAN, DCTPP1, XTP3TPA. Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DCTPP1

dCTP pyrophosphatase 1

DCTPP1

Molecular Synopsis