FEATURES

DESCRIPTION

Also known as ZFYV1_HUMAN, ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1. Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (PubMed:30970241). Regulates the morphology, size and distribution of LDs (PubMed:31293035, PubMed:30970241). Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 (PubMed:30970241). Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger (PubMed:11739631, PubMed:11256955). Interacts with RAB18 (in GTP-bound form) (PubMed:31293035, PubMed:30970241). Interacts with BSCL2 in a RAB18-dependent manner (PubMed:30970241). Interacts with ZW10 (PubMed:30970241).

Also known as ZFYV1_HUMAN, ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1. Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasi ...

EXTERNAL LINKS

ZFYVE1

Zinc finger FYVE domain-containing protein 1

ZFYVE1

Molecular Synopsis