FEATURES

FAMILY

DESCRIPTION

Also known as CRLF2_HUMAN, CRLF2, CRL2, ILXR, TSLPR. Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. Heterodimer of CRLF2 and IL7R.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CRLF2

Cytokine receptor-like factor 2

Mutations

Mutation(s) distribution

Mutations table

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